2,818 research outputs found
Application of computer techniques to some problems in linear viscoelasticity
Computer solutions in terms of molecular theories of linear viscoelasticit
Inhibition of DNA ejection from bacteriophage by Mg+2 counterions
The problem of inhibiting viral DNA ejection from bacteriophages by
multivalent counterions, specifically Mg counterions, is studied.
Experimentally, it is known that MgSO salt has a strong and non-monotonic
effect on the amount of DNA ejected. There exists an optimal concentration at
which the minimum amount of DNA is ejected from the virus. At lower or higher
concentrations, more DNA is ejected from the capsid. We propose that this
phenomenon is the result of DNA overcharging by Mg multivalent
counterions. As Mg concentration increases from zero, the net charge of
DNA changes from negative to positive. The optimal inhibition corresponds to
the Mg concentration where DNA is neutral. At lower/higher
concentrations, DNA genome is charged. It prefers to be in solution to lower
its electrostatic self-energy, which consequently leads to an increase in DNA
ejection. By fitting our theory to available experimental data, the strength of
DNADNA short range attraction energies, mediated by Mg, is found to
be 0.004 per nucleotide base. This and other fitted parameters agree
well with known values from other experiments and computer simulations. The
parameters are also in aggreement qualitatively with values for tri- and
tetra-valent counterions.Comment: 17 pages, 4 figures, improved manuscript. Submitted to J. Chem. Phys
(2010
Calcium-Rich Gap Transients: Tidal Detonations of White Dwarfs?
We hypothesize that at least some of the recently discovered class of
calcium-rich gap transients are tidal detonation events of white dwarfs (WDs)
by black holes (BHs) or possibly neutron stars. We show that the properties of
the calcium-rich gap transients agree well with the predictions of the tidal
detonation model. Under the predictions of this model, we use a follow-up X-ray
observation of one of these transients, SN 2012hn, to place weak upper limits
on the detonator mass of this system that include all intermediate-mass BHs
(IMBHs). As these transients are preferentially in the stellar haloes of
galaxies, we discuss the possibility that these transients are tidal
detonations of WDs caused by random flyby encounters with IMBHs in dwarf
galaxies or globular clusters. This possibility has been already suggested in
the literature but without connection to the calcium-rich gap transients. In
order for the random flyby cross-section to be high enough, these events would
have to be occurring inside these dense stellar associations. However, there is
a lack of evidence for IMBHs in these systems, and recent observations have
ruled out all but the very faintest dwarf galaxies and globular clusters for a
few of these transients. Another possibility is that these are tidal
detonations caused by three-body interactions, where a WD is perturbed toward
the detonator in isolated multiple star systems. We highlight a number of ways
this could occur, even in lower-mass systems with stellar-mass BHs or neutron
stars. Finally, we outline several new observational tests of this scenario,
which are feasible with current instrumentation.Comment: 10 pages, 1 figure, accepted for publication in MNRA
Weathering Behavior of Dimensionally Stabilized Wood Treated by Heating Under Pressure of Nitrogen Gas
With the goal of improving the weathering behavior of wood by reducing its hygroscopicity and accompanying dimensional changes, samples of spruce and beech were heat-treated under nitrogen pressure at 175 to 195 C and subjected to natural and artificial weathering. Beech had a significantly lower hygroscopicity and improved dimensional stability after heat treatment and was more resistant to weathering than the unheated control. Although the hygroscopicity of spruce was also significantly reduced by heat treatment, weathering resistance was diminished. Heat treatment of either species had small, but measurable effects on the performance and durability of semitransparent and film-forming stains applied to the samples
Development and Longevity: Cellular and Molecular Determinants - A Mini-Review
Across species, development and longevity are tightly linked. We discuss the relevant literature and suggest that the root for this stringent relationship is the rate of development. The basis for the relationship between rate of development and longevity lies in adaptations that have occurred through evolution at multiple levels of biological complexity: organism, organ, cellular, and molecular. Thus, the analysis of the relationship is of interest for multiple fields of biology
Examining the Effects of a Virtual Character on Learning and Engagement in Serious Games
Virtual characters have been employed for many purposes including interacting with players of serious games, with a purpose to increase engagement. These characters are often embodied conversational agents playing diverse roles, such as demonstrators, guides, teachers or interviewers. Recently, much research has been conducted into properties that affect the realism and plausibility of virtual characters, but it is less clear whether the inclusion of interactive agents in serious applications can enhance a user’s engagement with the application, or indeed increase efficacy. In a first step towards answering these questions, we conducted a study where a Virtual Learning Environment was used to examine the effect of employing a virtual character to deliver a lesso
THE RELATIONSHIP BETWEEN MUSCULOSKELETAL STRENGTH, PHYSIOLOGICAL CHARACTERISTICS, AND KNEE KINESTHESIA FOLLOWING FATIGUING EXERCISE
Fatiguing exercise may result in impaired functional joint stability and increased risk of unintentional injury. While there are several musculoskeletal and physiological characteristics related to fatigue onset, their relationship with proprioceptive changes following fatigue has not been examined. The purpose of this study was to establish the relationship between musculoskeletal and physiological characteristics and changes in proprioception, measured by threshold to detect passive motion (TTDPM), following fatiguing exercise. Twenty, physically active females participated (age: 28.65 ± 5.6 years, height: 165.6 ± 4.3 cm, weight: 61.8 ± 8.0 kg, BMI: 22.5± 2.3 kg/m2, BF: 23.3 ± 5.4%). During Visit 1, subjects completed an exercise history and 24-hour dietary questionnaire, and body composition, TTDPM familiarization, isokinetic knee strength, and maximal oxygen uptake/lactate threshold assessments. During Visit 2, subjects completed TTDPM and isometric knee strength testing prior to and following a fatiguing exercise protocol. Wilcoxon signed rank tests determined TTDPM and isometric knee strength changes from pre- to post- fatigue. Spearman’s rho correlation coefficients determined the relationship between strength and physiological variables with pre- to post-fatigue changes in TTDPM and with pre-fatigue and post-fatigue TTDPM in extension and flexion (α=0.05). No significant differences were demonstrated from pre-fatigue to post-fatigue TTDPM despite a significant decrease in isometric knee flexion strength (P<0.01) and flexion/extension ratio (P<0.05) following fatigue. No significant correlations were observed between strength or physiological variables and changes in TTDPM from pre- to post-fatigue in extension or flexion. Flexion/extension ratio was significantly correlated with pre-fatigue TTDPM in extension (r=-0.231, P<0.05). Peak oxygen uptake was significantly correlated with pre-fatigue (r=-0.500, P<0.01) and post-fatigue (r=-0.520, P<0.05) TTDPM in extension. No significant relationships were demonstrated between musculoskeletal and physiological characteristics and changes in TTDPM following fatigue. The results suggest that highly trained individuals may have better proprioception, and that the high fitness level of subjects in this investigation may have contributed to absence of TTDPM deficits following fatigue despite reaching a high level of perceptual and physiological fatigue. Future studies should consider various subject populations, other musculoskeletal strength characteristics, and different modalities of proprioception to determine the most important contributions to proprioceptive changes following fatigue
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